Cincinnati, Ohio
Medical Weight Loss
GLP-1 medications for weight loss offer an effective tool for individuals struggling with excess weight, especially when combined with a healthy diet and regular exercise. These medications can help reduce appetite, promote fat loss, and improve overall metabolic health. However, they require careful monitoring by a healthcare provider to manage side effects and ensure long-term success.
How GLP-1 Medications Work for Weight Loss
GLP-1 (glucagon-like peptide-1) weight loss medications, like semaglutide and terzepatide are a class of drugs that help people lose weight by influencing the body’s metabolism, appetite regulation, and insulin function. Here’s a breakdown of how GLP-1 medications work for weight loss and what you can expect:
Appetite Suppression:
- GLP-1 medications mimic the action of the naturally occurring GLP-1 hormone, which is released in the gut after eating.
- This hormone signals to the brain that you’re full, helping to reduce hunger and cravings. By activating GLP-1 receptors in the brain, these medications help you feel satisfied with smaller portions, making it easier to eat fewer calories.
Slower Gastric Emptying:
- GLP-1 medications slow down how quickly food leaves the stomach, which prolongs the feeling of fullness. This can help prevent overeating and the urge to snack between meals.
Improved Insulin Sensitivity:
- These medications enhance insulin production and sensitivity, which is particularly helpful for people with type 2 diabetes. By improving insulin response, GLP-1 medications can help regulate blood sugar levels, which in turn supports weight loss.
Reduced Fat Storage:
- GLP-1 medications may help promote the breakdown of fat and reduce fat storage, especially in areas like the abdomen. This can lead to fat loss, improving body composition over time.
Improved Metabolism:
- These drugs may also contribute to better metabolic function by improving blood sugar control, which can help people with metabolic syndrome or insulin resistance.
Expected Weight Loss Results
- Significant Weight Loss: Clinical trials have shown that GLP-1 medications can lead to a 10-20% reduction in body weight when combined with a reduced-calorie diet and regular physical activity.
- Gradual Process: Weight loss typically occurs gradually over several months. It’s important to note that individual results vary, with some people losing more weight than others.
- Maintenance of Weight Loss: Many patients are able to maintain their weight loss with continued use of GLP-1 medications, though lifestyle changes (diet, exercise) remain essential for long-term success.
Weight Loss Administration & Side Effects
Administration:
- Injection-Based: GLP-1 medications are typically administered through subcutaneous injections (under the skin), weekly depending on the specific medication
- Adjustable Dosing: Healthcare providers generally start with a lower dose to minimize side effects (like nausea) and gradually increase it over time as needed to the recommended dose for weight loss.
Side Effects:
While generally well-tolerated, GLP-1 medications can cause some side effects, particularly when starting treatment. These may include:
- Nausea: The most common side effect, especially when beginning treatment.
- Vomiting and Diarrhea: Some patients experience gastrointestinal discomfort.
- Headache: Can occur as the body adjusts to the medication.
- Fatigue: Some individuals report feeling more tired or sluggish.
- Stomach pain or bloating: Discomfort in the abdomen may occur in some cases.
These side effects typically improve over time as the body adjusts to the medication, but if they persist, it’s important to consult with a healthcare provider.
Who Is a Good Candidate for GLP-1 Medications?
Obesity or Overweight:
GLP-1 medications are prescribed to individuals who are overweight (BMI of 27 or higher) or obese (BMI of 30 or higher) and may have obesity-related health conditions (e.g., type 2 diabetes, hypertension).
Type 2 Diabetes:
People with type 2 diabetes or pre-diabetes may benefit from these medications not only for weight loss but also for improved blood sugar control.
Failed Weight Loss Attempts:
GLP-1 medications are often considered for patients who have struggled to lose weight through diet and exercise alone and are looking for medical support.
